What Are Longevity Drugs?
Longevity drugs are medication we can take to give us a boost in our goal of living healthier for longer.
As we age, our cells gradually become less efficient at repairing themselves. This process is known as cellular senescence, and it’s one of the main reasons why we experience age-related diseases and deterioration.
However, there are a number of pharmaceuticals that have been shown to slow or even reverse the effects of cellular senescence.
These drugs are known as senolytics or longevity drugs, and they’re becoming increasingly popular as a means of improving health and longevity.
Here are 10 things you can do today to live longer.
Resveratrol
One of the most well-known Longevity drugs is Resveratrol. David Sinclair is an expert in longevity drugs and especially this molecule.
Resveratrol is a compound that’s found in grapes and other plants and has been shown to have a number of health benefits, including anti-aging effects.
In particular, Resveratrol has been shown to improve the function of mitochondria, the powerhouses of our cells. It also helps to reduce inflammation and promote the production of new mitochondria.
Rapamycin
Rapamycin is another well-known longevity drug. It is an immunosuppressant that’s commonly used to prevent organ transplant rejection. However, Rapamycin has also been shown to have senolytic effects.
While Rapamycin is already approved for use in humans, it’s not yet clear whether it has the same senolytic effects in people as it does in animals.
However, there are some ongoing clinical trials testing the effects of Rapamycin in people with age-related diseases.
Some are available to be purchased (or prescribed by doctors) now. Others are undergoing research in laboratories around the globe and papers on the efficacy being published regularly.
Metformin
Metformin is a drug that’s commonly used to treat type 2 diabetes.
It’s also being studied as a possible treatment for other conditions, such as cancer and Alzheimer’s disease. Metformin may help to extend life span by mimicking some of the beneficial effects of calorie restriction.
In animal studies, metformin has been shown to increase lifespan and protect against age-related diseases. For example, one study found that metformin increased lifespan in mice by up to 14%.
Metformin may work by activating AMPK (AMP-activated protein kinase), an enzyme that plays a role in cell metabolism. AMPK has been shown to have anti-aging effects in animal studies.
Read this Harvard Medical School report on how Metformin can affect longevity.
NAD+
NAD+ is a compound that’s naturally found in all cells. Your NAD+ levels decline with age, and this is thought to contribute to the age-related deterioration of cells.
NAD+ is involved in numerous cellular processes, including energy production, DNA repair, and cell death.
Supplementing with NAD+ has been shown to reverse some age-related changes in cells, and it’s thought to have potential anti-aging effects.
If you’re interested in trying NAD+ supplements, look for a product that’s third-party tested and manufactured in an FDA-registered facility. These products will be of higher quality and more likely to be effective.
Nicotinamide Mononucleotide (NNM)
NNM, also known as Nicotinamide Mononucleotide, is a compound that’s been shown to increase lifespan in mice by up to 30%. It works by activating Sirtuins, which are proteins that regulate metabolism and aging.
NMN is currently being studied in humans and is thought to be safe and well-tolerated.
MCT Oil
Not exactly a longevity drug, MCT oil is a type of oil that’s derived from coconut. Unlike other oils, MCT oil is composed of medium-chain fatty acids, which the body can easily convert into ketones and use for energy.
This oil has become popular among people who follow a ketogenic diet or low-carb diet, as it helps increase energy levels and promote weight loss.
MCT oil is also being studied as a potential treatment for Alzheimer’s disease and other neurological disorders, as it may help improve cognitive function.
In a small study in healthy adults, supplementing with MCT oil increased levels of ketones in the blood and improved mental clarity and cognitive function.
Ginkgo Biloba
Ginkgo Biloba is a plant that’s native to Asia and has been used in traditional Chinese medicine for centuries. This extract is rich in antioxidants and is thought to help protect cells from damage.
In a small study, Ginkgo Biloba was shown to improve cognitive function in healthy adults.
Ginkgo Biloba is generally safe to consume, but it can cause gastrointestinal distress in some people.
Ostarine – MK-2866
MK-2866, also known as Ostarine, is a drug that works by mimicking the effects of calorie restriction, and has been shown to improve metabolism and reduce inflammation.
It is currently being studied as a potential treatment for age-related diseases such as Alzheimer’s and Parkinson’s.
Cardarine – GW-501516
Cardarine, also known as GW-501516, is a drug that works by activating AMPK, a key regulator of metabolism and energy expenditure.
It has been shown to increase endurance, improve fat burning, and protect against obesity and type II diabetes. In addition, Cardarine has anti-inflammatory and anti-cancer effects.
Andarine – S4
Andarine, also known as S4, is a drug that works by mimicking the effects of calorie restriction and improving mitochondrial function.
It is being studied as a potential treatment for age-related diseases such as sarcopenia, frailty, and Alzheimer’s disease.
Andarine is thought to work by activating sirtuins, a family of enzymes that play a role in regulating cell death and metabolism. Sirtuins have been linked to longevity in animals, and Andarine may help to extend the lifespan of humans by modulating these enzymes.
Andarine is currently being studied in clinical trials for its potential to treat age-related diseases.
Stenabolic – SR-9009
SR-9009, also known as Stenabolic, is a drug that works by stimulating Rev-ErbA, a protein that regulates metabolism and circadian rhythms.
In animal studies, SR-9009 has been shown to increase endurance and decrease fat storage. It also appears to have anti-inflammatory effects.
In humans, SR-9009 has been shown to improve metabolic health and increase muscle mass. It also appears to be safe and well-tolerated.
SR-9009 is a promising drug for the treatment of metabolic diseases and aging. However, more research is needed to confirm its efficacy and safety.
Ligandrol or Anabolicum – LGD-4033
Ligandrol has been shown to increase muscle mass and strength, as well as improve bone density and reduce body fat.
In addition, Ligandrol has been shown to increase lifespan in animal studies.
While Ligandrol is not yet approved by the FDA for human use, it is currently being studied as a potential treatment for age-related muscle loss and frailty.
Carbon60 – C60
C60 is made up of 60 carbon atoms arranged in a sphere. This unique structure gives it the ability to bind with free radicals, neutralizing them and preventing them from causing damage to cells.
Human studies are still in their early stages, but there is promising evidence that C60 could be a powerful anti-aging tool. One study found that people who took C60 had lower levels of oxidative stress and inflammation.
Another study found that people who took C60 had a decrease in the rate of telomere shortening. Telomeres are the protective caps at the end of chromosomes that shorten as we age. The shorter our telomeres, the closer we are to death.
So far, the evidence suggests that C60 is safe and well-tolerated by most people.
Spermidine
Spermidine is a compound that’s found in foods like soybeans, wheat, and corn. It’s been shown to increase lifespan in rats and is currently being studied in humans.
Spermidine has a variety of benefits, including prolonging life, reducing age-related diseases, and protecting cells from damage.
While more research is needed to confirm its efficacy, spermidine has the potential to change the way we age.
Summary
Longevity drugs are all relatively new, and more research is needed to confirm the efficacy in humans. However, the results from animal studies are promising, and they offer a potential way to live a longer and healthier life.
These drugs are known as senolytics, and they’re becoming increasingly popular as a means of improving health and longevity.
Rapamycin, Metformin, NAD+, and NNM are all currently being studied as potential longevity drugs.
If you’re interested in improving your health and longevity, talk to your doctor about whether senolytic drugs may be right for you.
IMPORTANT – This information is provided for your reference only and is not given as advice or a recommendation. You should always do your own research and speak to a medical professional before taking any form of pharmaceutical.
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